Ca2+ transporters and their role in the cancer hallmarks

Ca2+ transporters and their role in the cancer hallmarks

Calcium ion (Ca2+) activates crucial signaling pathways involved in different cellular processes, such as proliferation, cell cycle progression, apoptosis and gene expression. Ca2+ signaling depends on various proteins, including channels, pumps, receptors, and binding or storage proteins, which reg...

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Main Authors: Monge-Hernández, Indra Nicole, Santiago-García, Juan
Format: Online
Language:spa
Published: Universidad Autónoma de Tamaulipas 2024
Online Access:https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1917
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spelling oai:ojs.pkp.sfu.ca:article-19172024-07-19T23:51:52Z Ca2+ transporters and their role in the cancer hallmarks Transportadores de Ca2+ y su papel en las características distintivas del cáncer Monge-Hernández, Indra Nicole Santiago-García, Juan cáncer transportadores de calcio proliferación celular apoptosis migración e invasión celular cancer calcium transporters cell proliferation apoptosis cell migration and invasion Calcium ion (Ca2+) activates crucial signaling pathways involved in different cellular processes, such as proliferation, cell cycle progression, apoptosis and gene expression. Ca2+ signaling depends on various proteins, including channels, pumps, receptors, and binding or storage proteins, which regulate Ca2+ influx, compartmentalization, and concentration for Ca2+ dependent signaling pathways to function properly. This work aimed to analyze evidence regarding the altered expression of Ca2+ transporters in cancer and their contribution to the hallmarks of the disease, mainly sustained cellular proliferation, apoptosis resistance, and activation of migration and invasion. Evidence suggests that overexpression of Ca2+ channels in cancer is associated with increased Ca2+ entry and activation of CaM/CaN/NFAT, Akt or MAPK/ERK signaling pathways, leading to cell proliferation, migration, invasion, and epithelial-mesenchymal transition. On the other hand, the downregulation of Ca2+ pumps or upregulation of mitochondrial channels contributes to apoptosis evasion and enhanced cellular migration. Research on Ca2+ transporters with deregulated expression in cancer may contribute to the identification of potential biomarkers and therapeutic targets for the development of new treatments. El ion calcio (Ca2+) activa diversas vías de señalización importantes en diferentes procesos celulares como proliferación, progresión del ciclo celular, apoptosis y expresión génica. La homeostasis de Ca2+ depende de diversas proteínas, que actúan como canales, bombas, receptores, sitios de unión y almacenamiento de Ca2+, las cuales son de gran importancia porque regulan el flujo, compartimentación y concentración del Ca2+ celular, para que las vías de señalización dependientes de este catión funcionen adecuadamente. El objetivo del presente trabajo fue analizar la información existente sobre los cambios en la expresión de transportadores de Ca2+ en cáncer y su participación en las características distintivas de la enfermedad, principalmente la proliferación celular descontrolada, la resistencia a la apoptosis o la activación de la migración e invasión celular. La evidencia indica que múltiples canales de Ca2+ se sobreexpresan en cáncer, lo que se asocia con incremento del Ca2+ citoplásmico y activación de las vías de señalización CaM/CaN/NFAT, Akt o MAPK/ERK, situación que puede conducir a un incremento en la proliferación, transición epitelio-mesenquimal, mayor capacidad de migración e invasión celular. Por otro lado, la subexpresión de bombas de Ca2+ o sobreexpresión de canales mitocondriales contribuye a la evasión de la apoptosis, a la par que propicia la migración celular. El estudio de transportadores de Ca2+ con expresión alterada en cáncer puede contribuir a la identificación de potenciales biomarcadores o blancos terapéuticos que permitan el desarrollo de nuevas terapias. Universidad Autónoma de Tamaulipas 2024-09-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1917 10.29059/cienciauat.v19i2.1917 CienciaUAT; Vol 19 No. 2. January-June 2025 CienciaUAT; Vol. 19 No. 2: Enero-Junio 2025 2007-7858 2007-7521 spa https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1917/1246 https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1917/1249 Derechos de autor 2024 Universidad Autónoma de Tamaulipas https://creativecommons.org/licenses/by-nc-sa/4.0
institution CIENCIA UAT
collection OJS
language spa
format Online
author Monge-Hernández, Indra Nicole
Santiago-García, Juan
spellingShingle Monge-Hernández, Indra Nicole
Santiago-García, Juan
Ca2+ transporters and their role in the cancer hallmarks
author_facet Monge-Hernández, Indra Nicole
Santiago-García, Juan
author_sort Monge-Hernández, Indra Nicole
title Ca2+ transporters and their role in the cancer hallmarks
title_short Ca2+ transporters and their role in the cancer hallmarks
title_full Ca2+ transporters and their role in the cancer hallmarks
title_fullStr Ca2+ transporters and their role in the cancer hallmarks
title_full_unstemmed Ca2+ transporters and their role in the cancer hallmarks
title_sort ca2+ transporters and their role in the cancer hallmarks
description Calcium ion (Ca2+) activates crucial signaling pathways involved in different cellular processes, such as proliferation, cell cycle progression, apoptosis and gene expression. Ca2+ signaling depends on various proteins, including channels, pumps, receptors, and binding or storage proteins, which regulate Ca2+ influx, compartmentalization, and concentration for Ca2+ dependent signaling pathways to function properly. This work aimed to analyze evidence regarding the altered expression of Ca2+ transporters in cancer and their contribution to the hallmarks of the disease, mainly sustained cellular proliferation, apoptosis resistance, and activation of migration and invasion. Evidence suggests that overexpression of Ca2+ channels in cancer is associated with increased Ca2+ entry and activation of CaM/CaN/NFAT, Akt or MAPK/ERK signaling pathways, leading to cell proliferation, migration, invasion, and epithelial-mesenchymal transition. On the other hand, the downregulation of Ca2+ pumps or upregulation of mitochondrial channels contributes to apoptosis evasion and enhanced cellular migration. Research on Ca2+ transporters with deregulated expression in cancer may contribute to the identification of potential biomarkers and therapeutic targets for the development of new treatments.
publisher Universidad Autónoma de Tamaulipas
publishDate 2024
url https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1917
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AT santiagogarciajuan ca2transportersandtheirroleinthecancerhallmarks
AT mongehernandezindranicole transportadoresdeca2ysupapelenlascaracteristicasdistintivasdelcancer
AT santiagogarciajuan transportadoresdeca2ysupapelenlascaracteristicasdistintivasdelcancer
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