Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery

Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery

Microcarriers based on microcapsules and microspheres have been widely studied and tested to control the release of biotechnological drugs (BD), diminishing the dosage or modifying the route of administration. The methods for obtaining microcarriers are complex and varied, so it is necessary to dete...

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Main Authors: Zárate-Hernández, Elvia, Hernández-Esquivel, Rosa Alejandra, Pérez-Urizar, José Trinidad
Format: Online
Language:spa
Published: Universidad Autónoma de Tamaulipas 2021
Online Access:https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1472
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spelling oai:ojs.pkp.sfu.ca:article-14722021-01-30T20:05:10Z Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery Microcápsulas y microesferas: una visión a la caracterización integral y aplicación para la liberación de medicamentos biotecnológicos Zárate-Hernández, Elvia Hernández-Esquivel, Rosa Alejandra Pérez-Urizar, José Trinidad medicamento biotecnológico microesferas estabilidad proteica biotechnology drug microspheres protein stability Microcarriers based on microcapsules and microspheres have been widely studied and tested to control the release of biotechnological drugs (BD), diminishing the dosage or modifying the route of administration. The methods for obtaining microcarriers are complex and varied, so it is necessary to determine the minimum characteristics with which the system must comply. The aim of this work was to establish the main characteristics that should be evaluated in the microcarriers in order to guarantee that the biological activity of biotechnological drugs remains intact through the microencapsulation process, and therefore the safety of the BD (development of immune reactions) remains unaltered. The characteristics of a microcarrier to be evaluated must describe the properties of the material, the size and shape of the system, the particle load, functionalization, the microencapsulation efficiency, and the kinetics of liberation. Whereas the integrity of BD can be evaluated by critical quality parameter such as: structure and biological function of the BD, product purity, presence of high molecular weight aggregations, higher order structure and biological activity tests. The characterization of the microcarriers must focus on the safety of the bipolymer and proteins tested. Los microacarreadores basados en microcápsulas y microesferas han sido ampliamente estudiados y ensayados para controlar la liberación de medicamentos biotecnológicos (MB), disminuyendo la dosificación o modificando la vía de administración. Los métodos para la obtención de microacarreadores, son complejos y variados, por lo que es necesario determinar los requisitos mínimos que debe cumplir el sistema. El objetivo de este trabajo fue establecer las principales características que deben ser evaluadas en los microacarreadores para garantizar que la actividad biológica de los medicamentos biotecnológicos permanezca intacta a través del proceso de microencapsulación y, por lo tanto, que la seguridad del MB (desarrollo de reacciones inmunes) se mantenga inalterada. Las características a evaluar de un microacarreador deben describir las propiedades del material, tamaño y forma del sistema, carga de la partícula, funcionalidad, eficiencia de la microencapsulación y la cinética de liberación. Mientras que la integridad de los MB puede ser evaluada a partir de parámetros críticos de calidad: estructura y función biológica del MB, pureza del producto, presencia de agregados de alto peso molecular, estructura de orden superior y ensayos de actividad biológica. La caracterización de los microacarreadores debe enfocarse en la seguridad del biopolímero y proteínas ensayadas. Universidad Autónoma de Tamaulipas 2021-01-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html text/xml https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1472 10.29059/cienciauat.v15i2.1472 CienciaUAT; Vol 15 No. 2. January-June 2021; 21-36 CienciaUAT; Vol. 15 No. 2: Enero-Junio 2021 ; 21-36 2007-7858 2007-7521 spa https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1472/808 https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1472/809 https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1472/817
institution CIENCIA UAT
collection OJS
language spa
format Online
author Zárate-Hernández, Elvia
Hernández-Esquivel, Rosa Alejandra
Pérez-Urizar, José Trinidad
spellingShingle Zárate-Hernández, Elvia
Hernández-Esquivel, Rosa Alejandra
Pérez-Urizar, José Trinidad
Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery
author_facet Zárate-Hernández, Elvia
Hernández-Esquivel, Rosa Alejandra
Pérez-Urizar, José Trinidad
author_sort Zárate-Hernández, Elvia
title Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery
title_short Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery
title_full Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery
title_fullStr Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery
title_full_unstemmed Microcapsules and microspheres: A vision to integral characterization and applications for biotechnological drugs delivery
title_sort microcapsules and microspheres: a vision to integral characterization and applications for biotechnological drugs delivery
description Microcarriers based on microcapsules and microspheres have been widely studied and tested to control the release of biotechnological drugs (BD), diminishing the dosage or modifying the route of administration. The methods for obtaining microcarriers are complex and varied, so it is necessary to determine the minimum characteristics with which the system must comply. The aim of this work was to establish the main characteristics that should be evaluated in the microcarriers in order to guarantee that the biological activity of biotechnological drugs remains intact through the microencapsulation process, and therefore the safety of the BD (development of immune reactions) remains unaltered. The characteristics of a microcarrier to be evaluated must describe the properties of the material, the size and shape of the system, the particle load, functionalization, the microencapsulation efficiency, and the kinetics of liberation. Whereas the integrity of BD can be evaluated by critical quality parameter such as: structure and biological function of the BD, product purity, presence of high molecular weight aggregations, higher order structure and biological activity tests. The characterization of the microcarriers must focus on the safety of the bipolymer and proteins tested.
publisher Universidad Autónoma de Tamaulipas
publishDate 2021
url https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1472
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AT hernandezesquivelrosaalejandra microcapsulasymicroesferasunavisionalacaracterizacionintegralyaplicacionparalaliberaciondemedicamentosbiotecnologicos
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