Are experimental protocols an authentic simile of human diabetes?

For the study of diabetes, several methodological strategies use animal models. Such methodologies involve surgical techniques, diet modifications, some genetic manipulations and specific toxic drugs. The experimental production of diabetes in animal models use the administration of alloxan or strep...

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Main Authors:	Moreno-Cortés, María Luisa, Gutiérrez-García, Ana G., Contreras, Carlos M.
Format:	Online
Language:	spa
Published:	Universidad Autónoma de Tamaulipas 2020
Online Access:	https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1289
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spelling	oai:ojs.pkp.sfu.ca:article-12892020-07-31T23:34:40Z Are experimental protocols an authentic simile of human diabetes? ¿Los protocolos experimentales son un símil real de la diabetes humana? Moreno-Cortés, María Luisa Gutiérrez-García, Ana G. Contreras, Carlos M. experimental models diabetes alloxan streptozotocin hyperglycemia modelos experimentales diabetes aloxana estreptozotocina hiperglucemia For the study of diabetes, several methodological strategies use animal models. Such methodologies involve surgical techniques, diet modifications, some genetic manipulations and specific toxic drugs. The experimental production of diabetes in animal models use the administration of alloxan or streptozotocin and these drugs produce irreversible damage to pancreatic -cells. However, its use is associated to a ketosis high mortality rate due to the acute damage of pancreatic cells. The aim of this review consisted in the analysis of the pharmacological diabetes production protocols as well as other available strategies, in order to elucidate which is potentially the ideal protocol that emulates human diabetes. Diabetes is a progressive and chronic process, in which most of the clinical alterations are a long-term consequence of micro and macrovascular alterations. Therefore, it is convenient to establish a difference between the effects of acute hyperglycemia, with those effects observable when hyperglycemia is present over the long-term in order to reach enough analogies between the animal experimental model with the human diabetes syndrome, through the use of laboratory and clinical indicators commonly employed for the diagnoses and management of human diabetes. Para el estudio de la diabetes se dispone de diversas estrategias metodológicas en modelos animales, tales como, técnicas quirúrgicas, modificaciones dietéticas, incluso manipulación genética y la administración de fármacos específicos, por su toxicidad. En animales, la diabetes experimental se logra con el uso de fármacos, como la aloxana o la estreptozotocina, los cuales producen daño irreversible en las células-pancreáticas, aunque causan una alta mortalidad, debido a la cetosis asociada al daño agudo de estas células pancreáticas. El objetivo de este trabajo fue analizar los protocolos farmacológicos y otras estrategias disponibles, para determinar si la diabetes experimental realmente emula la diabetes humana. La diabetes es un proceso progresivo y crónico, en el que la mayor parte de las alteraciones clínicas son consecuencia, en el largo plazo, de alteraciones micro y macrovasculares. Por ello, es conveniente diferenciar entre los efectos de una hiperglucemia aguda, con aquellos que se observan cuando la hiperglucemia se prolonga a lo largo del tiempo, a fin de establecer analogías, entre el modelo experimental animal, con el síndrome diabético humano, mediante datos de laboratorio y de tipo clínico, de uso habitual en el diagnóstico y manejo de la diabetes humana. Universidad Autónoma de Tamaulipas 2020-01-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html text/xml https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1289 10.29059/cienciauat.v14i2.1289 CienciaUAT; Vol 14 No. 2. January-June 2020; 51-61 CienciaUAT; Vol. 14 No. 2: Enero-Junio 2020; 51-61 2007-7858 2007-7521 spa https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1289/664 https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1289/671 https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1289/768 Derechos de autor 2020 CienciaUAT
institution	CIENCIA UAT
collection	OJS
language	spa
format	Online
author	Moreno-Cortés, María Luisa Gutiérrez-García, Ana G. Contreras, Carlos M.
spellingShingle	Moreno-Cortés, María Luisa Gutiérrez-García, Ana G. Contreras, Carlos M. Are experimental protocols an authentic simile of human diabetes?
author_facet	Moreno-Cortés, María Luisa Gutiérrez-García, Ana G. Contreras, Carlos M.
author_sort	Moreno-Cortés, María Luisa
title	Are experimental protocols an authentic simile of human diabetes?
title_short	Are experimental protocols an authentic simile of human diabetes?
title_full	Are experimental protocols an authentic simile of human diabetes?
title_fullStr	Are experimental protocols an authentic simile of human diabetes?
title_full_unstemmed	Are experimental protocols an authentic simile of human diabetes?
title_sort	are experimental protocols an authentic simile of human diabetes?
description	For the study of diabetes, several methodological strategies use animal models. Such methodologies involve surgical techniques, diet modifications, some genetic manipulations and specific toxic drugs. The experimental production of diabetes in animal models use the administration of alloxan or streptozotocin and these drugs produce irreversible damage to pancreatic -cells. However, its use is associated to a ketosis high mortality rate due to the acute damage of pancreatic cells. The aim of this review consisted in the analysis of the pharmacological diabetes production protocols as well as other available strategies, in order to elucidate which is potentially the ideal protocol that emulates human diabetes. Diabetes is a progressive and chronic process, in which most of the clinical alterations are a long-term consequence of micro and macrovascular alterations. Therefore, it is convenient to establish a difference between the effects of acute hyperglycemia, with those effects observable when hyperglycemia is present over the long-term in order to reach enough analogies between the animal experimental model with the human diabetes syndrome, through the use of laboratory and clinical indicators commonly employed for the diagnoses and management of human diabetes.
publisher	Universidad Autónoma de Tamaulipas
publishDate	2020
url	https://revistaciencia.uat.edu.mx/index.php/CienciaUAT/article/view/1289
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Are experimental protocols an authentic simile of human diabetes?

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